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CD28-CD80 Interactions Control Regulatory T Cell Motility and Immunological Synapse Formation.

Abstract:

Regulatory T cells (Tregs) are essential for tolerance to self and environmental Ags, acting in part by downmodulating costimulatory molecules on the surface of dendritic cells (DCs) and altering naive CD4 T cell-DC interactions. In this study, we show that Tregs form stable conjugates with DCs before, but not after, they decrease surface expression of the costimulatory molecule CD80 on the DCs. We use supported planar bilayers to show that Tregs dramatically slow down but maintain a highly p...

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Publisher copy:
10.4049/jimmunol.1401752

Authors


Thauland, TJ More by this author
Koguchi, Y More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Parker, DC More by this author
Publisher:
American Association of Immunologists
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
193
Issue:
12
Pages:
5894-5903
Publication date:
2014-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:ebd7638f-1ff0-4bb8-8e7c-672204e010a7
Source identifiers:
488670
Local pid:
pubs:488670
Language:
English

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