Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids

Journal article

The synthesis and evaluation of 3-enaminetetramic acids as antibacterial agents is reported; contrary to the analogous 3-acyltetramic acids, the enaminetetramic acid class of compound exhibits modest antibacterial activity against a limited spectrum of organisms, and even that activity is strongly dependent on the identity of the tetramate ring substituents. Moreover, these compounds appear to have a different mode of action to the analogous 3-acyltetramic acids, and appear to offer more limited opportunity for further elaboration in drug discovery. © 2014 Elsevier Ltd. All rights reserved.

Authors: Jeong, Y; Anwar, M; Moloney, MG

• Publisher: Elsevier
• Journal: Bioorganic and Medicinal Chemistry Letters
• Volume: 24
• Issue: 8
• Pages: 1901-1906
• Publication date: 2014-04-15
• DOI: 10.1016/j.bmcl.2014.03.013
• EISSN: 1464-3405
• ISSN: 0960-894X
• Language: English
• Keywords: Tetramate; Enamine; Antibacterial