The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate.

Journal article

Patients with manic depressive disorder (DSM-III-R bipolar disorder) have an abnormality of the Na+,K(+)-ATPase pumps in their lymphocytes: the pump numbers do not upregulate to stimulation with lithium and ethacrynate. We have now investigated the in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase pumps in the first-degree unaffected relatives of patients with a clear history of manic depressive disorder. The lymphocytes of the healthy relatives upregulated their Na+,K(+)-ATPase pumps...

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Authors: Antia, I; Smith, C; Wood, A; Aronson, J

• Publication status: Published
• Journal: Journal of affective disorders
• Volume: 34
• Issue: 1
• Pages: 33-39
• Publication date: 1995-04-01
• DOI: 10.1016/0165-0327(94)00102-f
• EISSN: 1573-2517
• ISSN: 0165-0327
• Language: English
• Keywords: Sodium-Potassium-Exchanging ATPase; Humans; Ethacrynic Acid; Lymphocytes; Cells, Cultured; Lithium Chloride; Up-Regulation; Bipolar Disorder