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The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate.

Abstract:

Patients with manic depressive disorder (DSM-III-R bipolar disorder) have an abnormality of the Na+,K(+)-ATPase pumps in their lymphocytes: the pump numbers do not upregulate to stimulation with lithium and ethacrynate. We have now investigated the in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase pumps in the first-degree unaffected relatives of patients with a clear history of manic depressive disorder. The lymphocytes of the healthy relatives upregulated their Na+,K(+)-ATPase pumps...

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Journal:
Journal of affective disorders
Volume:
34
Issue:
1
Pages:
33-39
Publication date:
1995-04-05
DOI:
EISSN:
1573-2517
ISSN:
0165-0327
URN:
uuid:ebcf1e5c-aac5-4142-b231-f5dc86e70a22
Source identifiers:
322067
Local pid:
pubs:322067

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