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Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin.

Abstract:

Evidence suggests that nerve growth factor (NGF) is an important mediator in inflammatory pain states: NGF levels increase in inflamed tissue, and neutralization of endogenous NGF prevents the hyperalgesia which normally develops during inflammation of the skin. Here we asked whether NGF contributes to sensitization of primary afferent nociceptors, which are an important component of pain and hyperalgesia in inflamed tissue. An in vitro skin nerve preparation of the rat was used to directly r...

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Authors


Koltzenburg, M More by this author
Bennett, DL More by this author
Shelton, DL More by this author
McMahon, SB More by this author
Journal:
The European journal of neuroscience
Volume:
11
Issue:
5
Pages:
1698-1704
Publication date:
1999-05-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:ebc736cb-528a-4dd3-90ea-9d1358d65ffb
Source identifiers:
365807
Local pid:
pubs:365807

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