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Journal article

ED(27) trophoblast-like cells isolated from first-trimester chorionic villi are genetically identical to HeLa cells yet exhibit a distinct phenotype.

Abstract:

ED(27) trophoblast-like cells were prepared from human chorionic villus samples obtained at 9 weeks gestation and have been grown continuously in vitro without phenotypic drift for nearly a decade. These cells express many trophoblast markers, including cytokeratin, placental alkaline phosphatase (PLAP), secretion of 17beta-estradiol, and a microvillous apical surface. The ED(27) cell line is a useful model system for studies of placental cell biology and has been distributed to laboratories ...

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Publication status:
Published

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Publisher copy:
10.1053/plac.2001.0749

Authors


Linton, EA More by this author
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Journal:
Placenta
Volume:
23
Issue:
1
Pages:
32-43
Publication date:
2002-01-05
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
URN:
uuid:ebc61b94-ece3-49b5-b1c1-bda24bfa24b8
Source identifiers:
248288
Local pid:
pubs:248288

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