Type 1 Diabetes Mellitus and Alexithymia: A Systematic Review

Journal article : Review

Background: Alexithymia has been recognised as a predictor of negative outcomes in various chronic conditions, including type 2 diabetes mellitus (T2DM). However, evidence concerning its role in type 1 diabetes mellitus (T1DM) remains limited. This systematic review aims to explore the relationship between alexithymia and T1DM. Methods: In June 2025, following PRISMA guidelines, a systematic review was conducted using Scopus, PubMed, and Web of Science databases. Studies specifically addressing the relationship between alexithymia and type 1 diabetes mellitus were analysed. The search strategy included the keywords “Alexithymia” AND (“Type 1 Diabetes Mellitus” OR “T1DM”). The NIH Study Quality Assessment Tool was employed to evaluate the methodological quality of the selected studies. Results: Fifteen studies met the inclusion criteria. The systematic analysis of the literature highlighted three dominant themes: alexithymia was found to be associated with patients’ health status concerning weight and obesity, glycaemic control, and psychopathological symptoms. Moreover, alexithymia emerged as a potential predictor of adverse outcomes in T1DM self-management. Conclusions: Available evidence suggests that alexithymia has a clinically relevant impact on the management of T1DM. However, further research involving larger samples and longitudinal designs is needed to bridge the gap with other chronic conditions. Promoting evidence-based research in this area is aligned with the need for targeted psychological assessment, specific interventions, and improved care strategies.

Authors: Merlo, EM; Myles, LAM; Silvestro, O; Ruggeri, D; Russo, GT

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: MDPI
• Journal: Healthcare
• Volume: 13
• Issue: 19
• Article number: 2402
• Publication date: 2025-09-24
• Acceptance date: 2025-09-19
• DOI: 10.3390/healthcare13192402
• EISSN: 2227-9032
• ISSN: 2227-9032
• Language: English
• Keywords: alexithymia; T1DM; psychopathology; clinical psychology; type 1 diabetes mellitus; chronic disease
• Subtype: Review