Journal article

Thiyl glycosylation of olefinic proteins: S-linked glycoconjugate synthesis.

Abstract:: Tagged for thiolation: A novel glycoconjugation strategy utilizes a non-natural olefin-containing amino acid (homoallylglycine, Hag) as a "tag" for modification and a photoinitiated hydroglycothiolation reaction that is selective only for the Hag olefinic "tag". Application of this method to a number of model proteins allowed complete and precise site-selective glycosylate generating glycoconjugates that include, for example, virus-like particles displaying up to 180 glycans at preselected positions (see scheme). © 2009 Wiley-VCH Verlag GmbH and Co. KGaA.

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Floyd, N., Vijayakrishnan, B., Koeppe, J. R., & Davis, B. (2009). Thiyl glycosylation of olefinic proteins: S-linked glycoconjugate synthesis. Angewandte Chemie (International Ed. in English), 48(42), 7798–7802.

MLA Style

Floyd, N, et al. “Thiyl Glycosylation of Olefinic Proteins: S-Linked Glycoconjugate Synthesis.” Angewandte Chemie (International Ed. in English), vol. 48, no. 42, 2009, pp. 7798–802.

Chicago Style

Floyd, N, B Vijayakrishnan, JR Koeppe, and B Davis. 2009. “Thiyl Glycosylation of Olefinic Proteins: S-Linked Glycoconjugate Synthesis.” Angewandte Chemie (International Ed. in English) 48 (42): 7798–7802.
Print

Access Document

Publisher copy:: 10.1002/anie.200903135

Authors

+ Floyd, N More by this author

Role:: Author

+ Vijayakrishnan, B More by this author

Role:: Author

+ Koeppe, JR More by this author

Role:: Author

+ Davis, B More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Angewandte Chemie (International ed. in English) More from this journal
Volume:: 48
Issue:: 42
Pages:: 7798-7802
Publication date:: 2009-01-01
DOI:: 10.1002/anie.200903135
EISSN:: 1521-3773
ISSN:: 1433-7851

Language:: English
Keywords:: Amino Acids

Glycosylation

Glycoproteins

Alkenes

Sulfhydryl Compounds
Pubs id:: pubs:34878
UUID:: uuid:eba9799d-d3a6-4c04-a755-910e0fb7019d
Local pid:: pubs:34878
Source identifiers:: 34878
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_eba9799dd3a64c04a755910e0fb7019d

Terms of use

Copyright date:: 2009

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP