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A functional analysis of mouse models of cardiac disease through metabolic profiling.

Abstract:

Since the completion of the human and mouse genomes, the focus in mammalian biology has been on assessing gene function. Tools are needed for assessing the phenotypes of the many mouse models that are now being generated, where genes have been "knocked out," "knocked in," or mutated, so that gene expression can be understood in its biological context. Metabolic profiling of cardiac tissue through high resolution NMR spectroscopy in conjunction with multivariate statistics has been used to cla...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m410200200

Authors


Goddard, C More by this author
Mortishire-Smith, RJ More by this author
Sweatman, BC More by this author
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Journal:
The Journal of biological chemistry
Volume:
280
Issue:
9
Pages:
7530-7539
Publication date:
2005-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:eba27cc4-54c9-4d2f-9786-6353ffc8c9cd
Source identifiers:
106720
Local pid:
pubs:106720

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