Identification of inflammatory and proresolving lipid mediators in bone marrow and their lipidomic profiles with ovariectomy and omega-3 intake.

Journal article

Newly described lipoxygenase (LOX)-generated lipid mediators, that is, resolvins and protectins as well as lipoxins, are both anti-inflammatory and proresolving. We aimed to determine whether these lipid mediators are present in bone marrow and whether their lipidomic profiles are altered following ovariectomy or dietary supplementation with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) ethyl esters. Female rats were ovariectomised or sham-operated. Shams and one ovariectomised gr...

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Authors: Poulsen, R; Gotlinger, K; Serhan, C; Kruger, M

• Publication status: Published
• Journal: American journal of hematology
• Volume: 83
• Issue: 6
• Pages: 437-445
• Publication date: 2008-06-01
• DOI: 10.1002/ajh.21170
• EISSN: 1096-8652
• ISSN: 0361-8609
• Language: English
• Keywords: Fatty Acids, Omega-3; Rats; Female; Lipoxygenase; Docosahexaenoic Acids; Lipid Metabolism; Eicosapentaenoic Acid; Mass Spectrometry; Lipoxins; Bone Marrow; Inflammation; Lipids; Ovariectomy; Animals