Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.

Journal article

OBJECTIVES: Activation of ATP sensitive K+ channels (K(ATP)) and the NO-cGMP pathway have both been implicated in reducing norepinephrine (NE) release from cardiac sympathetic nerves during stimulation. Our aim was to test whether these pathways could interact and modulate cardiac excitability during sympathetic nerve stimulation (SNS). METHODS: The effect of inhibitors and activators of K(ATP) channels and the NO-cGMP pathway on the heart rate (HR) response to cardiac SNS in the isolated gui...

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Authors: Mohan, R; Paterson, D

• Publication status: Published
• Journal: Cardiovascular research
• Volume: 47
• Issue: 1
• Pages: 81-89
• Publication date: 2000-07-01
• DOI: 10.1016/s0008-6363(00)00057-2
• EISSN: 1755-3245
• ISSN: 0008-6363
• Language: English
• Keywords: Tolbutamide; Male; Guinea Pigs; Enzyme Inhibitors; Diazoxide; Glyburide; Anoxia; Cyclic GMP; Stellate Ganglion; Heart Atria; Heart Rate; Analysis of Variance; Electric Stimulation; Nitric Oxide; Potassium Channel Blockers; Sympathetic Nervous System; Norepinephrine; Potassium Channels; Animals