Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.

Journal article

Dopamine (DA) neurotransmission in the nucleus accumbens (NAc) is critically involved in normal as well as maladaptive motivated behaviors including drug addiction. Whether the striatal neuromodulator nitric oxide (NO) influences DA release in NAc is unknown. We investigated whether exogenous NO modulates DA transmission in NAc core and how this interaction varies depending on the frequency of presynaptic activation. We detected DA with cyclic voltammetry at carbon-fiber microelectrodes in mo...

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Authors: Hartung, H; Threlfell, S; Cragg, S

• Publication status: Published
• Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• Volume: 36
• Issue: 9
• Pages: 1811-1822
• Publication date: 2011-08-01
• DOI: 10.1038/npp.2011.62
• EISSN: 1740-634X
• ISSN: 0893-133X
• Language: English
• Keywords: Organ Culture Techniques; Nicotinic Antagonists; Dopamine; Synaptic Transmission; Interneurons; Nitric Oxide Donors; Presynaptic Terminals; Nitric Oxide; Mice; Male; Animals; Nucleus Accumbens; Up-Regulation; Acetylcholine; Mice, Inbred Strains