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Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer

Abstract:

Purpose: Expression of the type 1 insulin-like growth factor receptor (IGF1R) confers adverse prognosis in clear cell renal cell cancer (CC-RCC). We recently showed that IGF1R expression is inhibited by the von Hippel-Lindau (VHL) tumor suppressor, and the IGF1R is up-regulated in CC-RCC, in which VHL is frequently inactivated. We tested the hypothesis that IGF1R up-regulation mediates resistance to cancer therapeutics, evaluating the effects of IGF1R depletion on sensitivity to cytotoxic dru...

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Authors


Takiguchi, M More by this author
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Journal:
Molecular Cancer Therapeutics
Volume:
8
Issue:
6
Pages:
1448-1459
Publication date:
2009-06-05
DOI:
ISSN:
1535-7163
URN:
uuid:eb965728-2444-44ec-aecc-b3e2156caef4
Source identifiers:
178857
Local pid:
pubs:178857
Language:
English

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