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Fluorescent properties of DNA base analogue tC upon incorporation into DNA--negligible influence of neighbouring bases on fluorescence quantum yield.

Abstract:

The quantum yield of the fluorescent tricyclic cytosine analogue, 1,3-diaza-2-oxophenothiazine, tC, is high and virtually unaffected by incorporation into both single- and double-stranded DNA irrespective of neighbouring bases (0.17-0.24 and 0.16-0.21, respectively) and the corresponding fluorescence decay curves are all mono-exponential, properties that are unmatched by any base analogue so far. The fluorescence lifetimes increase when going from tC free in solution (3.2 ns) to single- and d...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gki790

Authors


Wilhelmsson, LM More by this author
Lincoln, P More by this author
Powers, VE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Nucleic acids research
Volume:
33
Issue:
16
Pages:
5019-5025
Publication date:
2005
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:eb8c6b27-757c-4704-8091-223aec9a2d4c
Source identifiers:
400205
Local pid:
pubs:400205

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