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Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.

Abstract:

1. To investigate the mechanisms regulating the reuptake of secretory granule membranes following regulated exocytosis, we have monitored changes in cell capacitance in single pancreatic beta-cells. 2. Membrane retrieval (endocytosis) occurred both in a continuous manner and in abrupt steps, corresponding to the simultaneous retrieval of 50-100 granules. The large endocytotic steps were associated with a conductance change of about 1 nS which we attribute to the formation of a fission pore wi...

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Publication status:
Published

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Authors


Eliasson, L More by this author
Ammälä, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Bokvist, K More by this author
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Journal:
The Journal of physiology
Volume:
493 ( Pt 3)
Issue:
3
Pages:
755-767
Publication date:
1996-06-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:eb8b678b-25ad-4ad7-b79d-23c50cd722b8
Source identifiers:
10815
Local pid:
pubs:10815

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