Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia.

Journal article

BACKGROUND: Hypothermia is one of the most robust experimental neuroprotective interventions against cerebral ischemia. Identification of molecular pathways and gene networks together with single genes or gene families that are significantly associated with neuroprotection might help unravel the mechanisms of therapeutic hypothermia. MATERIAL AND METHODS: We performed a microarray analysis of ischemic rat brains that underwent 90 min of middle cerebral artery occlusion (MCAO) and 48 h of rep...

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Authors: Nagel, S; Papadakis, M; Pfleger, K; Grond-Ginsbach, C; Buchan, A

• Publication status: Published
• Journal: Neuroscience
• Volume: 208
• Pages: 109-122
• Publication date: 2012-04-01
• DOI: 10.1016/j.neuroscience.2012.01.048
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Neural Pathways; Apoptosis; Software; Down-Regulation; Hemodynamics; Reperfusion; Magnetic Resonance Imaging; Microarray Analysis; Rats; Body Temperature; Rats, Wistar; Databases, Genetic; Ischemic Attack, Transient; Hypothermia, Induced; Real-Time Polymerase Chain Reaction; Animals; Gene Expression Profiling; Up-Regulation; RNA; Reproducibility of Results; Male; Infarction, Middle Cerebral Artery