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Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia.

Abstract:

BACKGROUND: Hypothermia is one of the most robust experimental neuroprotective interventions against cerebral ischemia. Identification of molecular pathways and gene networks together with single genes or gene families that are significantly associated with neuroprotection might help unravel the mechanisms of therapeutic hypothermia. MATERIAL AND METHODS: We performed a microarray analysis of ischemic rat brains that underwent 90 min of middle cerebral artery occlusion (MCAO) and 48 h of rep...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford
Pfleger, K More by this author
Grond-Ginsbach, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
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Journal:
Neuroscience
Volume:
208
Pages:
109-122
Publication date:
2012-04-05
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:eb81779a-2ef3-4c77-9531-2d1d6ba8d3b2
Source identifiers:
321510
Local pid:
pubs:321510

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