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CAMPATH-1 antibodies in stem-cell transplantation.

Abstract:

BACKGROUND: CAMPATH-1 (CD52) Abs have been used in stem-cell transplants for the prevention of GvHD and graft rejection. These complications can effectively be prevented by depletion of T lymphocytes from both donor and recipient. However, donor lymphocytes might contribute an anti-leukemia effect and lymphocyte depletion may exacerbate problems with immune reconstitution. There is a fine balance between the risks of GvHD and host-versus-graft reactions, relapse and infection. METHODS: Clini...

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Publication status:
Published

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Publisher copy:
10.1080/146532401753173981

Authors


Cobbold, S More by this author
Novitzky, N More by this author
Willemze, R More by this author
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Journal:
Cytotherapy
Volume:
3
Issue:
3
Pages:
145-164
Publication date:
2001
DOI:
EISSN:
1477-2566
ISSN:
1465-3249
URN:
uuid:eb7be8a3-644a-412c-94bb-2a90567d9d3c
Source identifiers:
29532
Local pid:
pubs:29532

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