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Quinine treatment of severe falciparum malaria in African children: a randomized comparison of three regimens.

Abstract:

The pharmacokinetics and effectiveness of three dosage regimens of quinine were studied in a group of 59 children with severe malaria. The children were randomized to receive high-dose intravenous or intramuscular quinine (20 mg salt/kg loading, then 10 mg salt/kg every 12 hr), or low-dose intravenous quinine (10 mg salt/kg loading, then 5 mg salt/kg every 12 hr). In the group receiving the high-dose intravenous regimen, mean high and low quinine concentrations were consistently greater than ...

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Publication status:
Published

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Authors


Newton, CR More by this author
Winstanley, PA More by this author
Watkins, WM More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
45
Issue:
6
Pages:
702-713
Publication date:
1991-12-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:eb75c300-064f-40f2-98c3-aa7f7d4cd831
Source identifiers:
43717
Local pid:
pubs:43717

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