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Journal article

Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies

Abstract:

The development of effective new treatments is greatly facilitated by the understanding of the mechanisms of disease. In rheumatoid arthritis, there has been progress in understanding its immunology, the HLA class II predisposition including the 'shared epitope' and more recently in understanding the importance of proinflammatory cytokines. Here we review our work in defining TNFα as a therapeutic target in rheumatoid arthritis, from an understanding of molecular pathogenesis in vitro, to for...

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Authors


Feldmann, M More by this author
Journal:
Joint Bone Spine
Volume:
69
Issue:
1
Pages:
12-18
Publication date:
2002
DOI:
ISSN:
1297-319X
URN:
uuid:eb75327b-6970-4202-b176-8e6acc632ec5
Source identifiers:
226196
Local pid:
pubs:226196

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