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Journal article

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.

Abstract:

Disruption of the creatine kinase (CK) system in hearts of CK-deficient mice leads to changes in the ultrastructure and regulation of mitochondrial respiration. We expected to see similar changes in creatine-deficient mice, which lack the enzyme guanidinoacetate methyltransferase (GAMT) to produce creatine. The aim of this study was to characterize the changes in cardiomyocyte mitochondrial organization, regulation of respiration, and intracellular compartmentation associated with GAMT defici...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00919.2012

Authors


Branovets, J More by this author
Kotlyarova, S More by this author
Jepihhina, N More by this author
Sokolova, N More by this author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
305
Issue:
4
Pages:
H506-H520
Publication date:
2013-08-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:eb740f4d-57b6-44a1-9448-56454af5b461
Source identifiers:
407654
Local pid:
pubs:407654

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