VEGF release is associated with reduced oxygen tensions in experimental inflammatory arthritis.

Journal article

OBJECTIVE: The contribution of local VEGF production and subsequent angiogenesis within the synovial membrane to the propagation of arthritis is unclear. The relationship between synovial oxygenation and blood flow in the development of arthritic disease is unknown. We have therefore measured oxygen levels and perfusion rates in the synovial space in a murine model of arthritis. METHODS: Arthritis was induced in DBA/1 mice by immunisation with type II collagen. Oxygen and perfusion levels wer...

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Authors: Etherington, P; Winlove, P; Taylor, P; Paleolog, E; Miotla, J

• Journal: Clinical and experimental rheumatology
• Volume: 20
• Issue: 6
• Pages: 799-805
• Publication date: 2002-01-01
• ISSN: 0392-856X
• Language: English
• Keywords: Joints; Oxygen Consumption; Intercellular Signaling Peptides and Proteins; Synovial Membrane; Freund's Adjuvant; Animals; Arthritis, Experimental; Polymerase Chain Reaction; Image Processing, Computer-Assisted; RNA, Messenger; Polarography; Lymphokines; Antigens, CD31; Mice; Vascular Endothelial Growth Factors; Collagen Type II; Vascular Endothelial Growth Factor A; Male; Oxygen; Microelectrodes; Endothelial Growth Factors