Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci.

McKenzie, CA; Julier, C; Forrester, T; McFarlane-Anderson, N; Keavney, B; Lathrop, GM; Ratcliffe, PJ; Farrall, M

Abstract:

Human serum angiotensin I-converting enzyme (ACE) levels vary substantially between individuals and are highly heritable. Segregation analysis in European families has shown that more than half of the total variability in ACE levels is influenced by quantitative-trait loci (QTL). One of these QTLs is located within or close to the ACE locus itself. Combined segregation/linkage analysis in a series of African Caribbean families from Jamaica shows that the ACE insertion-deletion polymorphism is...

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APA Style

McKenzie, C. A., Julier, C., Forrester, T., McFarlane-Anderson, N., Keavney, B., Lathrop, G. M., Ratcliffe, P. J., & Farrall, M. (1995). Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci. American Journal of Human Genetics, 57(6), 1426–1435.

MLA Style

McKenzie, C. A., et al. “Segregation and Linkage Analysis of Serum Angiotensin I-Converting Enzyme Levels: Evidence for Two Quantitative-Trait Loci.” American Journal of Human Genetics, vol. 57, no. 6, 1995, pp. 1426–35.

Chicago Style

McKenzie, CA, C Julier, T Forrester, N McFarlane-Anderson, B Keavney, GM Lathrop, PJ Ratcliffe, and M Farrall. 1995. “Segregation and Linkage Analysis of Serum Angiotensin I-Converting Enzyme Levels: Evidence for Two Quantitative-Trait Loci.” American Journal of Human Genetics 57 (6): 1426–35.
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