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Journal article

Possible structural abnormality of the brainstem in unipolar depressive illness: a transcranial ultrasound and diffusion tensor magnetic resonance imaging study.

Abstract:

BACKGROUND: Most empirically derived antidepressants increase monoamine levels. The nuclei of cells synthesising these monoamines are located in the brainstem, and projection tracts such as the medial forebrain bundle reach virtually all other brain areas. Two studies of unipolar depressive illness using transcranial ultrasound have reported reduced echogenicity of the brainstem midline in unipolar depressed patients. This may be consistent with disruption of white matter tracts, including th...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp.2004.057612

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
76
Issue:
11
Pages:
1510-1515
Publication date:
2005-11-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:eb6bfc30-2fe4-44ad-8ad5-32040c679d1e
Source identifiers:
139327
Local pid:
pubs:139327

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