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Reduction in precursors of cytotoxic T lymphocytes and of cells with natural killer-like activity in spleens of cyclophosphamide-treated mice.

Abstract:

The effect of cyclophosphamide (CY) on precursors of cytotoxic T lymphocytes (CTL), specific for Moloney-murine leukemia virus (M-MuL V)- induced antigens, and on the precursors of cells having natural killer (NK)-like activity was studied by means of limiting dilution assay. Pre-treatment with a single CY dose of 100 mg/kg induced a marked reduction not only in the total spleen cell number but also in the frequencies of M-MuL V-specific CTL, and NK-like cell precursors. Maximal effect was ob...

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Publication status:
Published

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Authors


Collavo, D More by this author
Ronchese, F More by this author
Zanovello, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Journal:
International journal of immunopharmacology
Volume:
6
Issue:
5
Pages:
529-534
Publication date:
1984
DOI:
ISSN:
0192-0561
URN:
uuid:eb557ccb-45de-4c64-97e6-42455aa846db
Source identifiers:
35473
Local pid:
pubs:35473

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