Reduction in precursors of cytotoxic T lymphocytes and of cells with natural killer-like activity in spleens of cyclophosphamide-treated mice.

Journal article

The effect of cyclophosphamide (CY) on precursors of cytotoxic T lymphocytes (CTL), specific for Moloney-murine leukemia virus (M-MuL V)- induced antigens, and on the precursors of cells having natural killer (NK)-like activity was studied by means of limiting dilution assay. Pre-treatment with a single CY dose of 100 mg/kg induced a marked reduction not only in the total spleen cell number but also in the frequencies of M-MuL V-specific CTL, and NK-like cell precursors. Maximal effect was obtained 2 days after CY injection, and a gradual recovery in both total spleen cell number and cytotoxic activity was achieved by day 12. These results confirm that CY exerts a strong but transient immunodepressive effect.

Authors: Collavo, D; Ronchese, F; Zanovello, P; Cerundolo, V; Biasi, G

• Publication status: Published
• Journal: International journal of immunopharmacology
• Volume: 6
• Issue: 5
• Pages: 529-534
• Publication date: 1984-01-01
• DOI: 10.1016/0192-0561(84)90092-4
• ISSN: 0192-0561
• Language: English
• Keywords: Mice, Inbred BALB C; Mice, Inbred C57BL; Mice; Killer Cells, Natural; T-Lymphocytes, Cytotoxic; Cyclophosphamide; Spleen; Animals