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Trans-hydrogen bond deuterium isotope effects of A:T base pairs in DNA.

Abstract:

The chemical shifts of (13)C2 of adenosine residues of DNA were observed to experience a through-space or trans-hydrogen bond isotope effect as a result of deuterium substitution at the imino hydrogen site of base-paired thymidine residues. NMR measurements of several self-complementary DNA duplexes at natural abundance (13)C in 50% H(2)O, 50% D(2)O solvent mixtures yielded an average trans-hydrogen bond isotope effect, (2h)Delta(13)C2, of -47 ppb. The data suggest that stronger hydrogen bond...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
Journal of biomolecular NMR
Volume:
29
Issue:
1
Pages:
65-72
Publication date:
2004-05-05
DOI:
EISSN:
1573-5001
ISSN:
0925-2738
URN:
uuid:eb3e67cb-e873-4628-8904-16877ff45837
Source identifiers:
196794
Local pid:
pubs:196794

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