Journal article
Trans-hydrogen bond deuterium isotope effects of A:T base pairs in DNA.
- Abstract:
-
The chemical shifts of (13)C2 of adenosine residues of DNA were observed to experience a through-space or trans-hydrogen bond isotope effect as a result of deuterium substitution at the imino hydrogen site of base-paired thymidine residues. NMR measurements of several self-complementary DNA duplexes at natural abundance (13)C in 50% H(2)O, 50% D(2)O solvent mixtures yielded an average trans-hydrogen bond isotope effect, (2h)Delta(13)C2, of -47 ppb. The data suggest that stronger hydrogen bond...
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- Publication status:
- Published
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- Publisher copy:
- 10.1023/b:jnmr.0000019507.95667.3e
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Authors
Bibliographic Details
- Journal:
- Journal of biomolecular NMR
- Volume:
- 29
- Issue:
- 1
- Pages:
- 65-72
- Publication date:
- 2004-05-01
- DOI:
- EISSN:
-
1573-5001
- ISSN:
-
0925-2738
- Source identifiers:
-
196794
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:196794
- UUID:
-
uuid:eb3e67cb-e873-4628-8904-16877ff45837
- Local pid:
- pubs:196794
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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