Journal article : Review

Crimson clues: advancing endometriosis detection and management with novel blood biomarkers

Abstract:: Endometriosis is an inflammatory condition affecting approximately 10% of the female-born population. Despite its prevalence, the lack of noninvasive biomarkers has contributed to an established global diagnostic delay. The intricate pathophysiology of this enigmatic disease may leave signatures in the blood, which, when detected, can be used as noninvasive biomarkers. This review provides an update on how investigators are utilizing the established disease pathways and innovative methodologies, including genome-wide association studies, next-generation sequencing, and machine learning, to unravel the clues left in the blood to develop blood biomarkers. Many blood biomarkers show promise in the discovery phase, but because of a lack of standardized and robust methodologies, they rarely progress to the development stages. However, we are now seeing biomarkers being validated with high diagnostic accuracy and improvements in standardization protocols, providing promise for the future of endometriosis blood biomarkers.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Gibbons, T., Rahmioglu, N., Zondervan, K. T., & Becker, C. M. (2024). Crimson clues: advancing endometriosis detection and management with novel blood biomarkers. Fertility and Sterility, 121(2), 145–163.

MLA Style

Gibbons, T., et al. “Crimson Clues: Advancing Endometriosis Detection and Management with Novel Blood Biomarkers.” Fertility and Sterility, vol. 121, no. 2, Elsevier, 2024, pp. 145–63.

Chicago Style

Gibbons, T, N Rahmioglu, KT Zondervan, and CM Becker. 2024. “Crimson Clues: Advancing Endometriosis Detection and Management with Novel Blood Biomarkers.” Fertility and Sterility 121 (2): 145–63.
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Publisher copy:: 10.1016/j.fertnstert.2023.12.018

Authors

+ Gibbons, T More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Research group:: Oxford Endometriosis CaRe Centre
Role:: Author

+ Rahmioglu, N More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Research group:: Oxford Endometriosis CaRe Centre
Role:: Author
ORCID:: 0000-0002-5169-8571

+ Zondervan, KT More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Research group:: Oxford Endometriosis CaRe Centre
Role:: Author
ORCID:: 0000-0002-0275-9905

+ Becker, CM More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Research group:: Oxford Endometriosis CaRe Centre
Role:: Author

Publisher:: Elsevier
Journal:: Fertility and Sterility More from this journal
Volume:: 121
Issue:: 2
Pages:: 145-163
Publication date:: 2024-02-02
Acceptance date:: 2023-12-13
DOI:: 10.1016/j.fertnstert.2023.12.018
EISSN:: 1556-5653
ISSN:: 0015-0282
Pmid:: 38309818

Language:: English
Keywords:: blood biomarkers

endometriosis

noninvasive test

diagnosis
Subtype:: Review
Pubs id:: 1615387
Local pid:: pubs:1615387
Deposit date:: 2025-03-10

Terms of use

Copyright holder:: American Society for Reproductive Medicine
Copyright date:: 2024
Rights statement:: ©2024 Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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