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Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture.

Abstract:

The activation segment of protein kinases is structurally highly conserved and central to regulation of kinase activation. Here we report an atypical activation segment architecture in human MPSK1 comprising a beta sheet and a large alpha-helical insertion. Sequence comparisons suggested that similar activation segments exist in all members of the MPSK1 family and in MAST kinases. The consequence of this nonclassical activation segment on substrate recognition was studied using peptide librar...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2007.10.026

Authors


Eswaran, J More by this author
Debreczeni, JE More by this author
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Journal:
Structure (London, England : 1993)
Volume:
16
Issue:
1
Pages:
115-124
Publication date:
2008-01-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:eb39041f-a36b-435d-8dc7-e221f70bfa06
Source identifiers:
34099
Local pid:
pubs:34099

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