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Journal article

Role of Ca2+ in the electrostatic stability and the functional activity of the globular domain of human C1q.

Abstract:

C1q is the recognition subunit of the classical pathway of the complement system and a major connecting link between classical pathway-driven innate immunity and IgG- or IgM-mediated acquired immunity. The basic structural subunit of C1q is composed of an N-terminal triple-helical collagen-like region and a C-terminal heterotrimeric globular head domain (gC1q) that is made up of individual A, B, and C chains. Recent crystallographic studies have revealed that the gC1q domain, which is the mai...

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Publication status:
Published

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Publisher copy:
10.1021/bi051186n

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Biochemistry
Volume:
44
Issue:
43
Pages:
14097-14109
Publication date:
2005-11-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:eb38aa7b-7a0e-4da3-9022-fefec9ee13e2
Source identifiers:
242836
Local pid:
pubs:242836

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