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Structure of a hexameric RNA packaging motor in a viral polymerase complex.

Abstract:

Packaging of the Cystovirus varphi8 genome into the polymerase complex is catalysed by the hexameric P4 packaging motor. The motor is located at the fivefold vertices of the icosahedrally symmetric polymerase complex, and the symmetry mismatch between them may be critical for function. We have developed a novel image-processing approach for the analysis of symmetry-mismatched structures and applied it to cryo-electron microscopy images of P4 bound to the polymerase complex. This approach allo...

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Publication status:
Published

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Publisher copy:
10.1016/j.jsb.2006.08.021

Authors


Huiskonen, JT More by this author
Jäälinoja, HT More by this author
Briggs, JA More by this author
Fuller, SD More by this author
Butcher, SJ More by this author
Journal:
Journal of structural biology
Volume:
158
Issue:
2
Pages:
156-164
Publication date:
2007-05-05
DOI:
EISSN:
1095-8657
ISSN:
1047-8477
URN:
uuid:eb2e98b8-653f-4c81-9e5c-1618571c098a
Source identifiers:
67848
Local pid:
pubs:67848

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