Proliferation and differentiation of human tenocytes in response to platelet rich plasma: an in vitro and in vivo study.

Journal article

Platelet rich plasma (PRP) is the autologous plasma fraction with a platelet-rich cellular component which is enriched with a number of growth factors. Due to its availability and low cost, PRP has become an increasingly popular clinical tool as an alternative source of growth factors for various applications, for example, tendon regeneration but with limited success in clinical trials. The main objective of the current study was to determine whether activated PRP [i.e., platelet rich plasma-...

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Authors: Wang, X; Qiu, Y; Triffitt, J; Carr, A; Xia, Z

• Publication status: Published
• Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• Volume: 30
• Issue: 6
• Pages: 982-990
• Publication date: 2012-06-01
• DOI: 10.1002/jor.22016
• EISSN: 1554-527X
• ISSN: 0736-0266
• Language: English
• Keywords: Basic Helix-Loop-Helix Transcription Factors; Humans; Collagen Type I; Culture Media; Clot Retraction; Wound Healing; Cattle; Cells, Cultured; Middle Aged; Tendons; Male; Animals; Platelet-Rich Plasma; Cell Differentiation; Female; Diffusion Chambers, Culture; Fetal Blood; Adult; Cell Proliferation; Gene Expression; Decorin