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Diversity and distribution of nuclease bacteriocins in bacterial genomes revealed using Hidden Markov Models

Abstract:

Bacteria exploit an arsenal of antimicrobial peptides and proteins to compete with each other. Three main competition systems have been described: type six secretion systems (T6SS); contact dependent inhibition (CDI); and bacteriocins. Unlike T6SS and CDI systems, bacteriocins do not require contact between bacteria but are diffusible toxins released into the environment. Identified almost a century ago, our understanding of bacteriocin distribution and prevalence in bacterial populations rem...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1005652

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Funding agency for:
Sharp, C
Grant:
Life Sciences Interface Doctoral Training Centre in Oxford
More from this funder
Funding agency for:
Maiden, M
Grant:
201505/Z/16/Z
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Funding agency for:
Kleanthous, C
Grant:
201505/Z/16/Z
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Grant:
collaborativeawardtoCK
MCJM(201505/Z/16/Z
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
13
Issue:
7
Article number:
e1005652
Publication date:
2017-07-17
Acceptance date:
2017-07-12
DOI:
ISSN:
1553-7358
Pubs id:
pubs:708352
UUID:
uuid:eb2b1133-2a14-42d9-9dcc-04280f067628
Local pid:
pubs:708352
Deposit date:
2017-07-17

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