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Diversity and distribution of nuclease bacteriocins in bacterial genomes revealed using Hidden Markov Models

Abstract:

Bacteria exploit an arsenal of antimicrobial peptides and proteins to compete with each other. Three main competition systems have been described: type six secretion systems (T6SS); contact dependent inhibition (CDI); and bacteriocins. Unlike T6SS and CDI systems, bacteriocins do not require contact between bacteria but are diffusible toxins released into the environment. Identified almost a century ago, our understanding of bacteriocin distribution and prevalence in bacterial populations rem...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1371/journal.pcbi.1005652

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Department:
Oxford, MSD, Biochemistry
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Author
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Department:
Oxford, MPLS, Zoology
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Author
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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Department:
Oxford, MPLS, Zoology
Role:
Author
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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Maiden, MCJ
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Funding agency for:
Kleanthous, C
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Grant:
collaborative award to CK and MCJM (201505/Z/16/Z)
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
13
Issue:
7
Pages:
Article: e1005652
Publication date:
2017-07-17
Acceptance date:
2017-07-12
DOI:
ISSN:
1553-7358
Pubs id:
pubs:708352
URN:
uri:eb2b1133-2a14-42d9-9dcc-04280f067628
UUID:
uuid:eb2b1133-2a14-42d9-9dcc-04280f067628
Local pid:
pubs:708352
Paper number:
7

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