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Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents

Abstract:
The α,β-unsaturated lactam 1b has been found to readily undergo conjugate addition reactions with a range of stabilised carbon nucleophiles and Reformatsky reagents under mild conditions in good yield with high diastereoselectivity. This method provides a simple and versatile approach to highly functionalised pyrrolidinones.
Publication status:
Published

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Publisher copy:
10.1016/0040-4039(96)00849-0

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
TETRAHEDRON LETTERS More from this journal
Volume:
37
Issue:
26
Pages:
4573-4576
Publication date:
1996-06-24
DOI:
ISSN:
0040-4039


Language:
English
Pubs id:
pubs:45243
UUID:
uuid:eb19541f-c78f-475d-a264-eae3778bf29f
Local pid:
pubs:45243
Source identifiers:
45243
Deposit date:
2012-12-19
ARK identifier:

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