Uptake of 99mTc-exametazime shown by single photon emission computerized tomography in obsessive-compulsive disorder compared with major depression and normal controls.

Journal article

Twelve patients with obsessive-compulsive disorder (OCD) were investigated at rest using single photon emission computerized tomography with 99mTc-exametazime. The uptake of 99mTc-exametazime was expressed relative to calcarine/occipital cortex. Patients were matched for drug treatment with 12 patients with a major depressive episode and the patient groups were compared with a control group. Significant bilateral decreases in tracer uptake were confined to basal ganglia in the OCD group. There was a paradoxical positive correlation between anxiety ratings and tracer uptake to basal ganglia in the OCD group. The findings confirm that the functional topography of OCD implicates altered function in the basal ganglia.

Authors: Edmonstone, Y; Austin, M; Prentice, N; Dougall, N; Freeman, C

• Journal: Acta psychiatrica Scandinavica
• Volume: 90
• Issue: 4
• Pages: 298-303
• Publication date: 1994-10-01
• DOI: 10.1111/j.1600-0447.1994.tb01597.x
• EISSN: 1600-0447
• ISSN: 0001-690X
• Language: English
• Keywords: Depressive Disorder; Tomography, Emission-Computed, Single-Photon; Brain; Basal Ganglia; Brain Mapping; Male; Adult; Middle Aged; Psychotropic Drugs; Female; Arousal; Organotechnetium Compounds; Cerebral Cortex; Obsessive-Compulsive Disorder; Humans; Anxiety Disorders; Oximes; Dominance, Cerebral; Technetium Tc 99m Exametazime