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Journal article

Refined linkage disequilibrium and physical mapping of the gene locus for X-linked dystonia-parkinsonism (DYT3).

Abstract:

X-linked dystonia-parkinsonism (XDP) is a recessive disorder characterized by generalized dystonia with some patients exhibiting parkinsonism. The disease gene, DYT3, is located between DXS453 (DXS993) and DXS559, and strongest linkage disequilibrium is found distal to DXS7117 and proximal to DXS559. We have isolated and analyzed four novel polymorphic markers between DXS7117 and DXS559 and, by haplotype analysis, have narrowed the candidate interval to <350 kb. A sequence-ready contig of ...

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Publication status:
Published

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Publisher copy:
10.1006/geno.1999.5929

Authors


Németh, AH More by this author
Niemann, S More by this author
Kostrzewa, M More by this author
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Journal:
Genomics
Volume:
60
Issue:
3
Pages:
320-329
Publication date:
1999-09-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:eb0f97a2-0346-4f8a-bd89-2d1e39e89cef
Source identifiers:
31552
Local pid:
pubs:31552

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