Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function.

Journal article

The c-Myc protein has been implicated in playing a pivotal role in regulating the expression of a large number of genes involved in many aspects of cellular function. Consistent with this view, embryos lacking the c-myc gene exhibit severe developmental defects and die before midgestation. Here, we show that Sox2Cre-mediated deletion of the conditional c-myc(flox) allele specifically in the epiblast (hence trophoectoderm and primitive endoderm structures are wild type) rescues the majority of...

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Authors: Dubois, N; Adolphe, C; Ehninger, A; Wang, R; Robertson, E

• Journal: Development (Cambridge, England)
• Volume: 135
• Issue: 14
• Pages: 2455-2465
• Publication date: 2008-08-01
• DOI: 10.1242/dev.022707
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: Hematopoietic Stem Cells; Female; Morphogenesis; Mice, Transgenic; Alleles; Immunohistochemistry; Cell Survival; Models, Biological; Pregnancy; Proto-Oncogene Proteins c-myc; Placenta; Erythroblasts; Mice; Animals