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Evidence for macromolecular protein rings in the absence of bulk water.

Abstract:

We have examined the architecture of a protein complex in the absence of bulk water. By determining collision cross sections of assemblies of the trp RNA binding protein, TRAP, we established that the 11-membered ring topology of the complex can be maintained within a mass spectrometer. We also found that the binding of tryptophan enhances the stability of the ring structure and that addition of a specific RNA molecule increases the size of the complex and prevents structural collapse. These ...

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Publisher copy:
10.1126/science.1120177

Authors


Ruotolo, BT More by this author
Campuzano, I More by this author
Sandercock, AM More by this author
Bateman, RH More by this author
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Journal:
Science
Volume:
310
Issue:
5754
Pages:
1658-1661
Publication date:
2005-12-09
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:eb0701a4-802e-4ba9-90d0-1bce725dcad5
Source identifiers:
59281
Local pid:
pubs:59281

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