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Improvement of serum alkaline phosphatase to <1.5 upper limit of normal predicts better outcome and reduced risk of cholangiocarcinoma in primary sclerosing cholangitis

Abstract:

Background and Aims: Normalization of serum alkaline phosphatase (SAP) was recently shown to correlate with better prognosis in Primary Sclerosing Cholangitis (PSC). We aimed at evaluating the impact of SAP improvement to below 1.5 the upper limit of normal (ULN) on the prognosis of this cholestatic liver disease. Methods: Oxford PSC database was screened for cases diagnosed between 1980 and 2004. Cases which met the inclusion criteria were retrospectively examined for clinical parameters, la...

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Publisher copy:
10.1016/j.jhep.2012.10.013

Authors


Al Mamari, S More by this author
Djordjevic, J More by this author
Halliday, JS More by this author
Chapman, RW More by this author
Journal:
Journal of Hepatology
Volume:
58
Issue:
2
Pages:
329-334
Publication date:
2013-02-05
DOI:
ISSN:
0168-8278
URN:
uuid:eb04d7e9-c68b-4708-aadf-8521898175d3
Source identifiers:
379596
Local pid:
pubs:379596

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