Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.

Journal article

China is a region of the world with a rapidly spreading HIV-1 epidemic. Studies providing insights into HIV-1 pathogenesis in infected Chinese are urgently needed to support the design and testing of an effective HIV-1 vaccine for this population. HIV-1-specific T cell responses were characterized in 32 HIV-1-infected individuals of Chinese origin and compared to 34 infected caucasians using 410 overlapping peptides spanning the entire HIV-1 clade B consensus sequence in an IFN-gamma ELISpot ...

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Authors: Yu, X; Addo, M; Perkins, B; Wej, F; Rathod, A

• Journal: AIDS research and human retroviruses
• Volume: 20
• Issue: 5
• Pages: 557-564
• Publication date: 2004-05-01
• DOI: 10.1089/088922204323087813
• EISSN: 1931-8405
• ISSN: 0889-2229
• Language: English
• Keywords: Humans; Enzyme-Linked Immunosorbent Assay; China; Genes, MHC Class I; Alleles; European Continental Ancestry Group; Cohort Studies; Amino Acid Sequence; HIV-1; Ethnic Groups; T-Lymphocytes; Molecular Sequence Data