Journal article
Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.
- Abstract:
-
The stimulation of Toll-like receptors (TLRs) on macrophages by pathogen-associated molecular patterns (PAMPs) results in the activation of intracellular signaling pathways that are required for initiating a host immune response. Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways are activated rapidly in response to TLR activation and are required to coordinate effective host responses to pathogen invasion. In this study, we analyz...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Molecular and cellular biology
- Volume:
- 33
- Issue:
- 21
- Pages:
- 4152-4165
- Publication date:
- 2013-11-01
- DOI:
- EISSN:
-
1098-5549
- ISSN:
-
0270-7306
- Source identifiers:
-
421133
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:421133
- UUID:
-
uuid:eaecf8c8-ce88-43b7-bedf-3c6fcdd2f45a
- Local pid:
- pubs:421133
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2013
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