Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.

Journal article

The stimulation of Toll-like receptors (TLRs) on macrophages by pathogen-associated molecular patterns (PAMPs) results in the activation of intracellular signaling pathways that are required for initiating a host immune response. Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways are activated rapidly in response to TLR activation and are required to coordinate effective host responses to pathogen invasion. In this study, we analyz...

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Authors: McGuire, V; Gray, A; Monk, C; Santos, S; Lee, K

• Publication status: Published
• Journal: Molecular and cellular biology
• Volume: 33
• Issue: 21
• Pages: 4152-4165
• Publication date: 2013-11-01
• DOI: 10.1128/mcb.01691-12
• EISSN: 1098-5549
• ISSN: 0270-7306
• Language: English
• Keywords: Phosphorylation; Pyridines; Animals; Signal Transduction; Macrophages; Pyridazines; Enzyme Activation; Cell Line; Protein-Serine-Threonine Kinases; Mice, Inbred C57BL; Lipopolysaccharides; Proto-Oncogene Proteins c-akt; Mice; Receptor Cross-Talk; Heat-Shock Proteins; Pyrimidines; Intracellular Signaling Peptides and Proteins; Mice, Transgenic; Protein Processing, Post-Translational; Phosphatidylinositol Phosphates; Mitogen-Activated Protein Kinase 14; Imidazoles; Neoplasm Proteins; Toll-Like Receptors