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Journal article

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.

Abstract:

The stimulation of Toll-like receptors (TLRs) on macrophages by pathogen-associated molecular patterns (PAMPs) results in the activation of intracellular signaling pathways that are required for initiating a host immune response. Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways are activated rapidly in response to TLR activation and are required to coordinate effective host responses to pathogen invasion. In this study, we analyz...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.01691-12

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Journal:
Molecular and cellular biology
Volume:
33
Issue:
21
Pages:
4152-4165
Publication date:
2013-11-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:eaecf8c8-ce88-43b7-bedf-3c6fcdd2f45a
Source identifiers:
421133
Local pid:
pubs:421133

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