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Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome.

Abstract:

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 10% of women of reproductive age. Women with anovulatory PCOS have hyperinsulinaemia, insulin resistance, and dyslipidaemia, and the syndrome is associated with greatly increased risks of non-insulin-dependent diabetes mellitus and cardiovascular disease and it often clusters in families. The VNTR (variable number of tandem repeats) locus upstream of the insulin gene (INS) regulates insulin expression...

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Publication status:
Published

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Authors


Waterworth, DM More by this author
Bennett, ST More by this author
Gharani, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Journal:
Lancet
Volume:
349
Issue:
9057
Pages:
986-990
Publication date:
1997-04-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:eaecdfa8-7d1a-4c0e-89ae-ac90ec72b22c
Source identifiers:
28421
Local pid:
pubs:28421

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