Objective: Epidemiological studies have shown an association between increased bone mineral density (BMD) and osteoarthritis (OA), but whether this represents cause or effect remains unclear. In this study, we used a novel approach to investigate this question, determining whether individuals with High Bone Mass (HBM) have a higher prevalence of radiographic hip OA compared with controls. Design: HBM cases came from the UK-based HBM study: HBM was defined by BMD Z-score. Unaffected relatives ...Expand abstract
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- Peer reviewed
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- W.B. Saunders Ltd Publisher's website
- Osteoarthritis and Cartilage Journal website
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- Copyright holder:
- Hardcastle et al.
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Copyright © 2014 The Authors. Published by Elsevier Ltd and Osteoarthritis Research Society International. This is
an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). Open Access funded by Wellcome Trust.