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Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations.

Abstract:

BACKGROUND: Alpha-synuclein is involved in dopaminergic neurotransmission and has been implicated in a number of neurodegenerative disorders, such as Parkinson's disease. Recent studies, in humans and in rat and monkey models, have suggested that alpha-synuclein may play a role in the development and maintenance of certain addictive disorders. METHODS: Fifteen single-nucleotide polymorphisms (SNPs) in the alpha-synuclein gene (SNCA) and 1 upstream microsatellite repeat (NACP-REP1) were assay...

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Authors


Clarimon, J More by this author
Williams, LN More by this author
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Journal:
Alcoholism, clinical and experimental research
Volume:
31
Issue:
4
Pages:
546-554
Publication date:
2007-04-05
DOI:
EISSN:
1530-0277
ISSN:
0145-6008
URN:
uuid:eae43fe8-520c-48cd-bdf8-65c410e109e3
Source identifiers:
315475
Local pid:
pubs:315475

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