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Two new dopamine agonists that are long acting in vivo but short acting in vitro.

Abstract:

The effects of two new ergolines, pergolide and CH29-717, on prolactin secretion in vitro and in vivo were compared with those of bromocriptine. Both ergolines had in vitro potencies similar to that of bromocriptine, but had a shorter duration of action. However, in vivo both were longer acting than bromocriptine after a single dose of 100 micrograms, and effectively suppressed prolactin secretion for greater than 24 h. It would appear that the pharmacokinetics of these ergolines are differen...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Clinical endocrinology
Volume:
13
Issue:
6
Pages:
595-599
Publication date:
1980-12-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:eae0742c-61b6-448c-ac16-93db32838192
Source identifiers:
138769
Local pid:
pubs:138769

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