Journal article

Two new dopamine agonists that are long acting in vivo but short acting in vitro.

Abstract:: The effects of two new ergolines, pergolide and CH29-717, on prolactin secretion in vitro and in vivo were compared with those of bromocriptine. Both ergolines had in vitro potencies similar to that of bromocriptine, but had a shorter duration of action. However, in vivo both were longer acting than bromocriptine after a single dose of 100 micrograms, and effectively suppressed prolactin secretion for greater than 24 h. It would appear that the pharmacokinetics of these ergolines are different to those of bromocriptine, and this may have considerable therapeutic importance.

Publication status:: Published

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APA Style

Grossman, A., Yeo, T., Delitala, G., Hathway, N., & Besser, G. (1980). Two new dopamine agonists that are long acting in vivo but short acting in vitro. Clinical Endocrinology, 13(6), 595–599.

MLA Style

Grossman, A, et al. “Two New Dopamine Agonists That Are Long Acting in Vivo but Short Acting in Vitro.” Clinical Endocrinology, vol. 13, no. 6, 1980, pp. 595–99.

Chicago Style

Grossman, A, T Yeo, G Delitala, N Hathway, and G Besser. 1980. “Two New Dopamine Agonists That Are Long Acting in Vivo but Short Acting in Vitro.” Clinical Endocrinology 13 (6): 595–99.
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Publisher copy:: 10.1111/j.1365-2265.1980.tb03428.x

Authors

+ Grossman, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: OCDEM
Role:: Author

+ Yeo, T More by this author

Role:: Author

+ Delitala, G More by this author

Role:: Author

+ Hathway, N More by this author

Role:: Author

+ Besser, G More by this author

Role:: Author

Journal:: Clinical endocrinology More from this journal
Volume:: 13
Issue:: 6
Pages:: 595-599
Publication date:: 1980-12-01
DOI:: 10.1111/j.1365-2265.1980.tb03428.x
EISSN:: 1365-2265
ISSN:: 0300-0664

Language:: English
Keywords:: Secretory Rate

Ergolines

Dose-Response Relationship, Drug

Prolactin

Bromocriptine

Rats

Male

Pergolide

Time Factors

Animals
Pubs id:: pubs:138769
UUID:: uuid:eae0742c-61b6-448c-ac16-93db32838192
Local pid:: pubs:138769
Source identifiers:: 138769
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_eae0742c61b6448cac1693db32838192

Terms of use

Copyright date:: 1980

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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