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Journal article

Perinatal glucocorticoid treatment produces molecular, functional, and morphological changes in the anterior pituitary gland of the adult male rat.

Abstract:

Stress or glucocorticoid (GC) treatment in perinatal life can induce long-term changes in the sensitivity of the hypothalamo-pituitary-adrenocortical axis to the feedback actions of GCs and, hence, in GC secretion. These changes have been ascribed largely to changes in the sensitivity of the limbic system, and possibly the hypothalamus, to GCs. Surprisingly, the possibility that early life stress/GC treatment may also exert irreversible effects at the pituitary level has scarcely been address...

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Publication status:
Published

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Publisher copy:
10.1210/en.2005-0500

Authors


Theogaraj, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Morris, JF More by this author
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Journal:
Endocrinology
Volume:
146
Issue:
11
Pages:
4804-4813
Publication date:
2005-11-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:eada7240-ff95-43e5-a6c2-26143a69c8a5
Source identifiers:
114690
Local pid:
pubs:114690

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