Understanding the host genetic susceptibility to typhoid fever may provide a better understanding of pathogenesis and help in the development of new therapeutics and vaccines. Here we determine the genetic variation within the human TLR4 gene encoding the principal receptor for bacterial endotoxin recognition in typhoid fever patients. It is possible that genetic variants of TLR4 could detrimentally affect the innate immune response against S. typhi infection. Mutation detection and genotypin...Expand abstract
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- Peer reviewed
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- Hue et al.
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- Citation: Hue, N. T. et al. (2009). 'Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam', PLoS ONE, 4(3): e4800. [Available at http://www.plosone.org]. © 2009 Hue et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam
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