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Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam

Abstract:

Understanding the host genetic susceptibility to typhoid fever may provide a better understanding of pathogenesis and help in the development of new therapeutics and vaccines. Here we determine the genetic variation within the human TLR4 gene encoding the principal receptor for bacterial endotoxin recognition in typhoid fever patients. It is possible that genetic variants of TLR4 could detrimentally affect the innate immune response against S. typhi infection. Mutation detection and genotypin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0004800

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Institution:
"University of Oxford", "Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"
Department:
Clinical Research Unit,Hospital for Tropical Diseases,Ho Chi Minh City,Vietnam
Role:
Author
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Institution:
"Dong Thap Provincial Hospital, Dong Thap, Vietnam"
Role:
Author
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Institution:
"Dong Thap Provincial Hospital, Dong Thap, Vietnam"
Role:
Author
More by this author
Institution:
"Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"
Role:
Author
More by this author
Institution:
"Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
4
Issue:
3
Pages:
Article: e4800
Publication date:
2009-03-05
DOI:
EISSN:
1932-6203
URN:
uuid:ead7495c-156c-4e07-b4fc-09342aa9023c
Local pid:
ora:2725
Language:
English
Keywords:
Subjects:

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