Cytochrome display on amyloid fibrils.

Journal article

Protein amyloid fibrils can be functionalized by coating the core protofilament with high concentrations of proteins and enzymes. This can be done elegantly by appending a functional domain to an amyloidogenic protein monomer, then assembling the monomers into a fibril. To display an array of biologically functional porphyrins on the surface of protein fibrils, we have fused the sequence of the small, soluble cytochrome b562 to an SH3 dimer sequence that can form classical amyloid fibrils rap...

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Authors: Baldwin, A; Bader, R; Christodoulou, J; MacPhee, C; Dobson, C

• Publication status: Published
• Journal: Journal of the American Chemical Society
• Volume: 128
• Issue: 7
• Pages: 2162-2163
• Publication date: 2006-02-01
• DOI: 10.1021/ja0565673
• EISSN: 1520-5126
• ISSN: 0002-7863
• Language: English
• Keywords: Heme; Nuclear Magnetic Resonance, Biomolecular; Amyloid; Cytochromes b; Microscopy, Electron, Transmission; Circular Dichroism