A bioinformatics search pipeline, RNA2DSearch, identifies RNA localization elements in Drosophila retrotransposons.

Journal article

mRNA localization is a widespread mode of delivering proteins to their site of function. The embryonic axes in Drosophila are determined in the oocyte, through Dynein-dependent transport of gurken/TGF-alpha mRNA, containing a small localization signal that assigns its destination. A signal with a similar secondary structure, but lacking significant sequence similarity, is present in the I factor retrotransposon mRNA, also transported by Dynein. It is currently unclear whether other mRNAs exis...

Expand abstract

Authors: Hamilton, R; Hartswood, E; Vendra, G; Jones, C; Van De Bor, V

• Publication status: Published
• Journal: RNA (New York, N.Y.)
• Volume: 15
• Issue: 2
• Pages: 200-207
• Publication date: 2009-02-01
• DOI: 10.1261/rna.1264109
• EISSN: 1469-9001
• ISSN: 1355-8382
• Language: English
• Keywords: Animals; Oocytes; Terminal Repeat Sequences; Nucleic Acid Conformation; Sequence Alignment; Base Sequence; Drosophila melanogaster; Retroelements; Transforming Growth Factor alpha; Genome, Insect; Drosophila Proteins; Molecular Sequence Data; Sequence Analysis, RNA; RNA, Messenger