- Abstract:
-
The use of recombinant T cell receptors (TCRs) to target therapeutic interventions has been hindered by the naturally low affinity of TCR interactions with peptide major histocompatibility complex ligands. Here, we use multimeric forms of soluble heterodimeric alphabeta TCRs for specific detection of target cells pulsed with cognate peptide, discrimination of quantitative changes in antigen display at the cell surface, identification of virus-infected cells, inhibition of antigen-specific cyt...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m409427200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 280
- Issue:
- 3
- Pages:
- 1882-1892
- Publication date:
- 2005-01-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:eabf4290-c484-4658-9f06-3019ed1a1003
- Source identifiers:
-
374540
- Local pid:
- pubs:374540
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
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