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Journal article

Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.

Abstract:

The use of recombinant T cell receptors (TCRs) to target therapeutic interventions has been hindered by the naturally low affinity of TCR interactions with peptide major histocompatibility complex ligands. Here, we use multimeric forms of soluble heterodimeric alphabeta TCRs for specific detection of target cells pulsed with cognate peptide, discrimination of quantitative changes in antigen display at the cell surface, identification of virus-infected cells, inhibition of antigen-specific cyt...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m409427200

Authors


Boulter, JM More by this author
Vuidepot, A More by this author
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Journal:
The Journal of biological chemistry
Volume:
280
Issue:
3
Pages:
1882-1892
Publication date:
2005-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:eabf4290-c484-4658-9f06-3019ed1a1003
Source identifiers:
374540
Local pid:
pubs:374540

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