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Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease.

Abstract:

BACKGROUND: Chronic neurodegeneration results in microglial activation, but the contribution of inflammation to the progress of neurodegeneration remains unclear. We have shown that microglia express low levels of proinflammatory cytokines during chronic neurodegeneration but are "primed" to produce a more proinflammatory profile after systemic challenge with bacterial endotoxin (lipopolysaccharide [LPS]). METHODS: Here, we investigated whether intraperitoneal (IP) challenge with LPS, to mimi...

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Publication status:
Published

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Authors


Cunningham, C More by this author
Campion, S More by this author
Murray, CL More by this author
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Journal:
Biological psychiatry
Volume:
65
Issue:
4
Pages:
304-312
Publication date:
2009-02-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:eab6a487-5b9f-4e3c-803b-b69e480196e4
Source identifiers:
293771
Local pid:
pubs:293771

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