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Direct and indirect control of orexin/hypocretin neurons by glycine receptors

Abstract:

Hypothalamic hypocretin/orexin (hcrt/orx) neurons promote arousal and reward seeking, while reduction in their activity has been linked to narcolepsy, obesity and depression. However, the mechanisms influencing the activity of hcrt/orx networks in situ are not fully understood. Here we show that glycine, a neurotransmitter best known for its actions in the brainstem and spinal cord, elicits dose-dependent postsynaptic Cl - currents in hcrt/orx cells in acute mouse brai...

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Authors


Karnani, MM More by this author
Jensen, LT More by this author
Burdakov, D More by this author
Journal:
Journal of Physiology
Volume:
589
Issue:
3
Pages:
639-651
Publication date:
2011-02-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:eab47afa-e878-46ee-8f94-0fe3b102b107
Source identifiers:
314925
Local pid:
pubs:314925
Language:
English

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