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Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

Abstract:

Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B4 (LTB4). TT homozygotes, with increased expression of LTA4H, have the highest survival when treated with dexamethasone and the lowest survival without. While the T allele is present in only a minority of...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.2024852118

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Role:
Author
ORCID:
0000-0002-8232-4601
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Role:
Author
ORCID:
0000-0002-0280-1800
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Role:
Author
ORCID:
0000-0002-4069-5279
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
118
Issue:
10
Article number:
e2024852118
Publication date:
2021-03-03
Acceptance date:
2020-12-10
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
33658385
Language:
English
Keywords:
Pubs id:
1167450
Local pid:
pubs:1167450
Deposit date:
2021-04-16

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